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71 Due to the challenges linked to macromolecular drugs crossing the BBB and their inability to target specific sites and ineffective dosages, nanotherapeutics have gained significant attention for drug delivery to the CNS and targeting microglia-related neuroinflammation

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25, 38 As aberrations in the TP53 gene and t(4:14) translocations are seen in ∼15% of patients 49 and correlated with short progression-free survival and resistance to alkylating agents at relapse, 50 the ability of BSO to sensitize MM cells with this phenotype suggests that BSO+L-PAM may have clinical activity in the most aggressive forms of MM

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